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Active research projects

''DECIDE –Dynamic information system creation for purposes of data arrangement of biobank and social scientific activities, quality control and integration''

Aim of the project is to develop prototype of dynamic system informative agreement and questionnaires, with a purpose to integrate results of academic research done within biobank with initiative of society, at the same time providing reliability of the data, using hierarchial harmonization of metadata and research into the ethical, legal and social impact (ELSI) on society.

Principal investigator: Dr. biol. Vita Rovīte

Funded by ERAF project No. 1.1.1.1/20/A/047.

 

''Development of an integrated database of genome variations in the Latvian population and it's application for determining the genetic risk of individualized matabolic diseases''

The aim of the project is to develop first map of Latvian genome variation, evaluate precise, population connected polygenetic risk scores. For this purpose, the resurces of the national biobank - the Latvian State genome database will be used, creating a functional framework for a personalized, omics-based prevention and treatment program in Latvia.

Principal investigator: Dr. biol. Jānis Kloviņš

Funded by ERAF project No. 1.1.1.1/20/A/126.

 

"Development of COVID-19 related sample biobank and associated data integrated platform in Latvia"

Aim of the project if to create centralized biobank and data exchange platform, promoting activities to control the spread of the virus, the development of the new treatments and international cooperation.

Principal investigator: Dr. biol. J. Kloviņš

Funded by State Research Program project No. VPP-COVID-2020/1-0016.

 

"Effect of Nordic diet on intestinal microbiome composition, function and fatigue symptoms in patients with mild to moderate ulcerative colitis"

The main goal of the project is to evaluate the composition and functional profile of the intestinal microbiome, fatigue and other clinical symptoms in patients with ulcerative colitis before and after a short Nordic diet.

Principal investigator: Dr. biol. Vita Rovīte

The study is funded by CALL FOR NATIONAL PROJECT at NORDIC-BALTIC REGION BIOCODEX MICROBIOTA FOUNDATION 2020 “Gut Microbiota in Human Health and Diseases” project No. Biocodex - PRL / 20/10.

 

"Interaction and dynamics of secretory IgA and intestinal microbioma during antidiabetic therapy"

The project aims to understand the modulatory effects of sIgA on the gut microbiome, especially in T2D patients, and the role of metformin in this process, using human clinical trials and an appropriate T2D mouse model to identify reliable omics-based biomarkers for prognosis and new treatment strategies.

Principal investigator: Dr. biol. Jānis Kloviņš

The study is funded by ERDF project No. 1.1.1.1/19/A/036.

 

''A dynamic human microbiome data platform and interpretation tool for personalized health recommendations ''

The main goal of the project is to develop a multifunctional, cloud-based data collection and analysis platform that, based on microbiome analyzes and available evidence-based scientific information, would provide personalized dietary, lifestyle and drug treatment recommendations.

Principal investigator: Dr. biol. Jānis Kloviņš

The study is funded by ERDF project No. KC-PI-2020/30.

 

"Integration of knowledge and biobank resources in the development of personalized prevention and treatment of metabolic diseases using a comprehensive translation approach (INTEGROMED)"

The result of the project will be achieved based on three main objectives: (1) To improve and optimize the use of resources provided by large biobanks and prospective research cohorts together with the national health care system, improve knowledge in clinical trials to develop new precision medical approaches; (2) Strengthen the training of collaborative professionals in the field of multi-omics approaches, bioinformatics and modeling to increase excellence in the implementation of advanced multi-omics technologies in areas such as genomics, DNA methylation and gene expression profile, microbiome and metabolome analysis; (3) Develop a long-term strategy and sustainability plan, involving all stakeholders, ensure the development and training of clinical applications and entrepreneurial skills to create an innovation-friendly ecosystem around LBMC.

Principal investigator: Dr.biol. Jānis Kloviņš

The project is funded by Horizon 2020 project No. H2020-WIDESPREAD-2018-2020.

 

'' Clinical significance of human and microbiomic transcriptome in extracellular vesicles ''

The main goal of this project is to gain new knowledge about the content and origin of EV RNA in the blood of cancer patients and to study their potential application in the diagnosis, prognosis and early detection of three different types of cancer - prostate, breast and gastric cancer.

Principal investigator: Dr. biol. Aija Linē

The study is funded by ERDF project No. 1.1.1.1/18/A/084.

 

"Identification of clinical subtypes of type 2 diabetes and the applicability of pharmacogenetics in the development of personalized antidiabetic therapy"

The scientific goal of the research is to identify the risk groups of patients with type 2 diabetes (2TD) and to investigate personalized antidiabetic therapy by performing large-scale genetic analysis and data processing with the latest data processing and analysis methods. , biopharmaceuticals and biotechnology ”). In parallel with the scientific goal, a postdoctoral position will be established in the Latvian Biomedical Research and Study Center (BMC), where the research application will be implemented (according to SAM).

Principal investigator: Dr. biol. Raitis Pečulis

The project is funded by ERDF project No. 1.1.1.2/VIAA/2/18/287.

 

"Investigation of the origin and dynamics of human blood microbiome, and its role in chronic disease"

The main aim of this project is to understand the origin and dynamics of human blood microbiome and its association with intestinal inflammation in order to identify reliable omics-based biomarkers for early detection and monitoring of chronic conditions using type 2 diabetes, irritable bowel syndrome and inflammatory bowel disease models.

Principal investigator: Dr. biol. Jānis Kloviņš

Funded by Grant from Latvian Council of Science No: lzp-2019/1-0116.

 

"Multidisciplinary study of community-acquired sepsis survivors in Latvia"

The primary objective of the study is to obtain in-depth understanding on the sepsis survivors, including clinical, molecular aspects of the recovery from illness.

Principal investigator: Dr. med. Uga Dumpis, principal investigator from Latvian Biomedical centre Dr. biol. Jānis Kloviņš

Funded by Grant from Latvian Council of Science No: lzp-2019/1-0225.

 

"Establishing an algorithm for the early diagnosis and follow-up of patients with pancreatic neuroendocrine tumors - NEXT"

The present proposal aim to identify PNET-specific biomarkers urgently needed to design a next generation nanotechnology based microfluidic device and integrate the technology of minimally invasive liquid biopsy in the early detection of PNETs by building up a tissue bank of genetically characterized tumours, development of patient-derived rare tumour xenografts (PDXs) and organoids.

Principal investigator: Dr. biol. Vita Rovīte

Research is funded by Joint Transnational Call for Proposals 2017.

 

„The determination of rare inherited diseases' causative mechanisms using whole genome sequencing approach”

The aim of the project is to identify novel causative genetic elements in rare inherited disease patients in whom pathogenic variants have not been identified so far by conventional genetic analysis approaches.

Principal investigator: Dr. biol. Inna Iņaškina

Research is funded by the ERDF project No. 1.1.1.1/18/A/096.

 

“RNA molecular determinants in development of pituitary adenoma”

The objective of the project is to study the spectrum of various ribonucleic acid (RNA) markers (mRNA, non-coding) in development of pituitary adenoma to discover determinants that influence therapy response and disease outcome.

Principal investigator: Dr. biol. Vita Rovīte

Research is funded by the ERDF project No. 1.1.1.1/18/A/089.

 

„Functional and genetic research of rare unidentitied neuromuscular disorders”

The aim of the project focuses on two topics: 1) to better understand and characterize the recently identified mutant MYBPC1 protein, its interactions with other cellular partners, and the molecular mechanisms underlying newly described disease phenotype; 2) using the newest molecular biology methods, namely whole genome sequencing, to identify novel causative genetic elements (genes, inter-gene regions or chromosomal rearrangements) for rare and/or unidentified neuromuscular disorders.

Principal investigator: Dr. biol. Inna Iņaškina

Research is funded by the ERDF project No. 1.1.1.1/18/A/097.

 

„Role of miRNAs in the host-gut microbiome communication during metformin treatment in the context of metabolic disorders”

The aim of the project is to investigate the contribution of the host miRNAs in metformin-mediated changes in gut microbiome composition and functions in the context of type 2 diabetes and to identify miRNAs which could be directed to potential clinical studies.

Principal investigator: Prof. Jānis Klovins

Research is funded by the ERDF project No. 1.1.1.1/18/A/092.