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Work reports

Report of the activities of Genome Database of Latvian popuation in 2017.

Category List
Research projects

Infromation about research projects available here.

Publications
  • McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nat Commun. 2017 Mar 21;8:14774.
  • Sviklāne L, Olmane E, Dzērve Z, Kupčs K, Pīrāgs V V, Sokolovska J. Fatty liver index and hepatic steatosis index predict non-alcoholic fatty liver disease in type 1 diabetes. J Gastroenterol Hepatol. 2017 May 2.
  • A New Baltic Population-Specific Human Genetic Marker in the PMCA4 Gene. Stavusis J, Inashkina I, Lace B, Pelnena D, Limborska S, Khrunin A, Kucinskas V, Krumina A, Piekuse L, Zorn B, Fodina V, Punab M, Erenpreiss J. Hum Hered. 2016;82(3-4):140-146. doi: 10.1159/000481434. Epub 2017 Nov 2.
  • Rovite V, Wolff-Sagi Y, Zaharenko L, Nikitina-Zake L, Grens E, Klovins J. Genome Database of the Latvian Population (LGDB): design, goals, and primary results. Journal of Epidemiology. Accepted August 6th, 2017, in press.
  • Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins. Association of metformin administration with gut microbiome dysbiosis in healthy volunteers. The Journal of Pharmacology and Experimental Therapeutics.
Conference thesis
  • A. Babre, E. Zole, V. Igumnova, I. Jansone, R.Ranka. Screening for mitochondrial DNA mutations C1494T and A1555G in tuberculosis patients in Latvia. Rīga Stradiņš University International student conference Health and social sciences, Riga, Latvia, 5 April 2017, Abstracts, p.104.
  • Zaiceva L., Jansons J., Dovbenko A., Petrovskis I., Skrastina D., Sominskaya I. “Detection of antibodies against HCV core and its alternative reading frame protein in patient serum” The international conference” Vaccines and Vaccination” Moscow, September 27-October 1, 2017, p.61.
  • Janis Klovins, Ilze Elbere, Raitis Peculis, Ineta Kalnina, Linda Zaharenko, Ilze Konrade & Valdis Pirags, Alterations in DNA methylation from peripheral blood cells in humans threated with metformin. 19th European Congress of Endocrinology, Lisbon, Portugal. Endocrine Abstracts (2017) 49 OC6.3.
  • Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Ilze Radovica, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins. Changes induced by a weeklong metformin treatment in the human gut microbiome. AZ Nordic Baltic Diabetes Science Forum. Gothenburg, Sweden (2017).
  • Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Ilze Radovica, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins. Association of metformin treatment with gut microbiome dysbiosis in healthy volunteers. 2nd annual Europan Microbiome Congress. London, UK (2017).
  • Nordic-Baltic Diabetes Science Forum, Translational and Clinical Metabolic Research, Swened, 19-20.01.2017. Sviklāne L., Olmane E., Dzērve Z., Kupčs K. and Sokolovska J. „A pilot study for validation of hepatic steatosis indices in patients with type 1 diabetes mellitus”.
  • ESHG European Human Genetics Conference 2017, Denmark, “A novel mutation in MYBPC1 is associated with myopathy, tremor, and spinal rigidity”. Janis Stavusis, Baiba Lace, Janelle Geist, Inna Inashkina, Dita Pelnena, Sander Pajusalu, Aikaterini Kontrogianni-Konstantopoulos, and Carsten G Bönnemann.
  • 14th Conference of the Baltic Child Neurology Association, Latvia, “Limb-Girdle Muscular Dystrophies - the current state in Latvia and Lithuania”. Janis Stavusis, Inna Inashkina, Dita Pelnena, Ieva Micule, Jurgis Strautmanis, Maruta S. Naudina, Loreta Cimbalistiene, Vaidutis Kucinskas, Astrida Krumina, Algirdas Utkus, Birute Burnyte, Ausra Matuleviciene, Baiba Lace.
  • 75th University of Latvia conference, Latvia “Novel MYBPC1 gene mutation association with previously undescribed miopathy in family of Latvia”. Jānis Stāvusis, Baiba Lāce, Janelle Geist, Inna Iņaškina, Dita Pelnēna, Sander Pajusalu, Aikaterini Kontrogianni-Konstantopoulos, and Carsten G Bönnemann.
Sample access
  • DNA samples - 3333
  • Serum and plasma aliquots - 636
Other activities
  • Develpoment of Latvian Biobank legal act project.
  • Obtained permissions from Data State Inspectorate (permission No. 006018) to use state medical records for research. The pilot project is carried out to evaluate efficacy of type two diabetes treatment in Latvia.
  • BBMRI-ERIC partner charter has been signed.
  • Genome Database is included in BBMRI-ERIC biobank catalogue Directory.